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You should not use Desvenlafaxine if you are allergic to desvenlafaxine or venlafaxine (Effexor), or if you are being treated with methylene blue injection.

Do not use Desvenlafaxine if you are taking an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. You must wait at least 14 days after stopping an MAOI before you can take Desvenlafaxine. After you stop taking Pristiq, you must wait at least 7 days before you start taking an MAOI.

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Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Desvenlafaxine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. Desvenlafaxine may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment.

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